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66 KokkalaP.MpakaliA.MauvaisF.-X.PapakyriakouA.DaskalakiI.PetropoulouI.et al (2016)

When a connective target suffers severe mechanical trauma, the resulting micro-tears rapidly drop local oxygen tension, creating an ischemic cellular environment

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In preclinical models, inhibiting this receptor has been shown to mimic some of the physiological effects of endurance exercise