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Clin Diabetes (2020) 38(1):10911

R., Kapoor, M

NAION Diagnosis and Long-Term Impact NAION is typically diagnosed by an ophthalmologist or neuro-ophthalmologist through: A comprehensive eye exam Optic nerve imaging Visual field testing Review of medical history and medication use There is currently no proven treatment that can reverse optic nerve damage caused by NAION

Topiramate is an antiepileptic drug, and this class carries an FDA warning about increased risk of suicidal thoughts and behavior

Less controversially, the second phase is likely caused by direct stimulation of L-cells by digested nutrients

Altogether, initial reports of NAD + precursors and exercise in clinical trials, while encouraging in certain instances, are still too inconclusive to directly link an increase in NAD + levels and mitochondrial metabolism to established health benefits in humans