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5.1 Comprehensive strategy combining multiple medication classes A recent actuarial modeling study assessed the potential clinical benefits of combining three major pharmacologic classesSGLT2 inhibitors, GLP-1 receptor agonists, and the non-steroidal MRA finerenoneusing data from large-scale randomized trials (161)

Maghsoodi N, Shaw N, Cross GF, et al

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The authors noted that the effect sizes were meaningful but modest, and that strain specificity was a significant factor in determining outcomes

Ensure adequate magnesium intake through dark leafy greens, nuts, seeds, or supplementation with 200-400mg of magnesium glycinate daily, a form particularly beneficial for anxiety

Dose adjustments should only be made under the direction of a licensed healthcare provider