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In a study at the University of Zurich with 23 patients with coronary artery disease, endothelial function was assessed by measuring the flow-mediated dilatation (FMD) of the brachial artery (9)

Peptides that influenced multiple physiological pathways were often deemed too complex for therapeutic development, particularly when early studies revealed off-target effects at supraphysiologic doses

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it resulted from the continuous activation of the GLP1 pathway

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