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Despite multiple studies in the field, there is still no consensus on the most suitable animal models that could representatively demonstrate the pathogenesis of GC side effects

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Nonetheless, our observed association between thyroid hormone over-replacement and new-onset AF/Aflutter aligns with a nested casecontrol study of 183,360 patients: compared to low levothyroxine exposure, high and medium exposure was associated with 29% (95% CI 1.231.35) and 8% (95% CI 1.041.11) increased odds of AF, respectively [36]

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Hills RA, Tan TK, Cohen AA, Keeffe JR, Keeble AH, Gnanapragasam PNP, et al

Among different classes, Phi and Tau class GSTs are plant-specific and predominantly present, whereas the smaller Theta and Zeta classes, having restricted xenobiotic activity, are also found in animals