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The result is a two-sided weight-loss effect: reduced caloric intake from appetite suppression plus increased caloric output from thermogenesis

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Nonetheless, its remarkable impact on brain receptors related to appetite and insulin production has captured the medical communitys attention

The Core is supported in part by an NCI Cancer Center Support Grant # NIH P30 CA016359

Pharmacologically, KEAP1 activity can be inhibited by the compound bardoxolone (CDDO) 68