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Administration is typically intranasal at 300 to 600 mcg once or twice daily, or subcutaneous at 300 to 500 mcg daily

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Borgonetti V, Vozella V, Ware T, Cruz B, Bullard R, Cravatt BF, Galeotti N, Roberto M (2024) Excessive alcohol intake produces persistent mechanical allodynia and dysregulates the endocannabinoid system in the lumbar dorsal root ganglia of genetically-selected Marchigian Sardinian alcohol-preferring rats

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Importantly, these analogues retain biological activity and display improved metabolic stability towards CYP1A-mediated metabolism

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