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Cell death at this time point was indiscriminate, as the lesion site was largely devoid of neuronal (NeuN + ), astrocytic (GFAP + ), oligodendrocyte (APC + ), and microglia (Iba1 + ) staining (all in green)

Although FOXO4 is present in a small fraction of normal cells, its expression is significantly increased in senescent cells 34

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