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Key Takeaway: Unopened GLP-1 medications are typically stable in the refrigerator until their printed expiration or beyond-use date, but they must never be allowed to freeze

However, they are most effective when coupled with sustainable changes in diet and physical activity

100:4059-4066 [PMC free article: PMC4702444] [PubMed: 26305617] 125

Adding topiramate could theoretically enhance this outcome, but at the cost of increased tolerability concerns

Vitamin B12 deficiency is something that can happen to anyone, but it is especially prevalent in people aged 50 and older

Several companies, such as Pfizer (PF-07976016), Regor Therapeutics (RGT-075), AstraZeneca (AZD5004), and others, are also evaluating their oral GLP-1 candidates to give competition to Novo and Eli Lilly