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Furthermore, patients who did not receive zinc supplementation experienced longer recovery times, worse clinical presentations, and higher mortality rates compared to those who received supplemental zinc [407]

Increased blood glucose levels induce excessive mitochondrial fission or fragmentation, thereby affecting OXPHOS, inhibit the expression of PINK1 and Parkin and downregulate the expression of genes such as PGC-1, thereby inhibiting mitochondrial biogenesis and mitophagy and preventing cells from eliminating abnormal mitochondria

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References DeFoor MT, Dekker TJ