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Sirtuins, nicotinamide adenine dinucleotide (NAD + )-dependent histone deacetylases, catalyze various deacylations

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Similar content being viewed by others Introduction Glutathione (GSH) deficiency is one of the earliest biochemical perturbations in Parkinsons disease (PD), 1,2 leading to the hypothesis that GSH supplementation may have therapeutic value in alleviating PD symptoms or modifying progression