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In gene knockdown assay, GLP-1R siRNA#1 demonstrated a significant decrease in the levels of GLP-1R mRNA and protein (Supplemental Fig

This may have influenced endogenous GLP-1 measurements due to receptor-mediated feedback inhibition, as previously described [12, 13]

Lifestyle Advice Maintain a balanced diet rich in fiber to support digestive health

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Electrolyte Support: Consider electrolyte-rich drinks, especially if experiencing significant GI losses, to replenish essential minerals

GLP-1 receptor agonists typically require patients to be at least 18 years old for weight loss indication, though this varies by specific medication and indication