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1 Introduction Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia (elevated blood glucose), which is caused by a lack of insulin or failure of insulin, resulting in cells being unable to absorb glucose, thus increasing blood glucose levels

As women move through perimenopause and beyond, hormonal shifts already influence muscle mass, sleep quality, metabolic resilience, and recovery

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Specifically, treatment with exenatide acetate increased the ratio of p -AMPKThr172/AMPK, inhibited NF-B p65 phosphorylation, and downregulated pro-inflammatory markers, including IL-1 and TNF- [69]

Liraglutide (Victoza), injectable semaglutide (Ozempic), and dulaglutide (Trulicity) have demonstrated statistically significant reductions in major adverse cardiovascular events in clinical trials