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[DOI] [PubMed] [Google Scholar] 158.Ludwig DS, Tritos NA, Mastaitis JW, et al

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Garcinia Cambogia A review of eight clinical trials found an average weight loss of approximately 1.34 kg with Garcinia cambogia supplementation

This effect may be due either to inhibition of carbamyl phosphate synthase (CPS) I by -oxidation metabolites (CPS I is the first mitochondrial enzymatic step of the urea cycle) or to decreased synthesis of N -acetyl glutamic acid (NAGA) from acetyl-CoA and glutamate by NAGA synthetase (NAGA is an important cofactor of CPS I)