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It is usually supplemented as L-leucine, the free form used in precision amino acid formulation in aquafeeds

Long-term safety and efficacy studies in humans are still ongoing, and large-scale trials are needed to confirm its therapeutic benefits

For each transcript, the table reports the log 2 -transformed average gProcessed signal from three biological replicates, the fold change between the various experimental groups expressed as log 2 ratio (LPS vs control and BSO/LPS vs LPS) and the respective P -value for each comparison, obtained by two-tailed Students t -test

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Together, these findings underscore that the cGASSTING pathway is not only a molecular sentinel for pathogen detection but also a critical driver linking mitochondrial stress and mtDNA release to chronic neuroinflammation in NDDs

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