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Plasma protein binding of duloxetine is not affected by renal or hepatic impairment

Novel insight into the molecular make-up of AMYRs and central signaling reinforces its key function in modulating homeostatic and hedonic feeding mechanisms

For testing the interaction of other MAX2HTL(SMXL) components, the proteins were mixed in a 1:1.5:1.2 molar ratio to a final 150 L volume with roughly 0.25 mg of the MAX2 protein, and corresponding amounts of the binding partners, following the same procedure as above