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The next wave dual and triple agonists (GLP-1 + GIP + glucagon: tirzepatide, retatrutide, survodutide) are showing superior fat loss, better hepatic outcomes, and potentially preserved lean mass

Activation of AKT2 also leads to the phosphorylation and inhibition of glycogen synthase kinase-3 (GSK3), which is a major regulatory kinase of glycogen homeostasis

Instrumental variables regression with weak instruments

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Ro (Ro Body) Discontinued compounded GLP-1 programs

This is an exciting avenue for future research