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Multiple injections are usually required to achieve optimal outcomes

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The operative note must document the approach, and the code must reflect it

Lancet 376(9742):687697 Hurvitz SA et al (2018) Neoadjuvant trastuzumab, pertuzumab, and chemotherapy versus trastuzumab emtansine plus pertuzumab in patients with HER2-positive breast cancer (KRISTINE): a randomised, open-label, multicentre, phase 3 trial

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