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Supplementary material The Supplementary Material for this article can be found online at: References 1 AbdelmasihR.SaeedZ.AshrafB.AbdelmaseihR.NasserH

Although the milestone of the treatment of obesity in PWS is the prevention that could occur thanks to growth hormone (GH) therapy and lifestyle interventions started in childhood [32], nutritional interventions along with the use of current antiobesity drugs provide evidence to be effective in adult subjects with obesity [44]

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When Hashimoto's disrupts the gut microbiome, it potentially reduces the body's natural GLP-1 production, contributing to the metabolic dysfunction that makes weight management so difficult

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