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Appetite remains suppressed, but without the accompanying gastrointestinal distress that made eating difficult during month 2

But the consistency of results across hundreds of participants injecting at various times of day strongly supports the conclusion that efficacy is time-independent, while tolerability is time-dependent

As insulin resistance worsens, the pancreas works increasingly hard to maintain glucose control

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For this drug, the ongoing SOUL trial has shown promising preliminary results, indicating a 14% reduction in the risk of MACE (84)

The mid-2027 approval estimate is based on current trajectory