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Effect of sodium-glucose cotransporter 2 inhibitors on cardiovascular and kidney outcomessystematic review and meta-analysis of randomized placebo-controlled trials

I would also like to thank David L Ludwig for valuable discussions about the physiology and pharmacology of GLP-1 and for careful reading and commenting on the manuscript

Side effects can persist after a dose change Because GLP1 levels taper gradually rather than dropping to zero, symptoms can continue for days or even weeks after a dose change

Clinical trials of sodiumglucose cotransporter 2 (SGLT2) inhibitors and glucagon-like peptide 1 (GLP1) receptor agonists have shown beneficial effects of these agents on kidney outcomes in patients with type 2 diabetes mellitus