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It predicts all-cause mortality independent of serum B12

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MOTS-c levels were observed to correlate with endothelial function markers in research, with treatment datasets showing measurement shifts in vascular signaling

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It also helps in reversing the imbalance of matrix metalloproteinases (MMP-9) and their inhibitors (TIMP-1), and in preventing epithelial-mesenchymal transition (EMT) through the modulation of Nrf2, NF-B, and TGF-1/Smad2/3 signaling pathways 6