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Addiction circuitry in the human brain
According to the MHRA product information, the most frequently reported adverse reactions include: Nausea and vomiting : Very common (affecting more than 1 in 10 people), typically most pronounced during the first 48 weeks of treatment or following dose escalation Diarrhoea : Common (affecting up to 1 in 10 people), with frequency increasing at higher doses Abdominal pain or discomfort : Often described as cramping or bloating sensations Decreased appetite : A direct result of the medication's action on satiety centres Constipation : Less common than diarrhoea but can occur in some individuals Dyspepsia (indigestion) : Characterised by upper abdominal discomfort or burning The timing of these side effects follows a predictable pattern in most patients
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The two paths are not the same, and confusing them is how patients end up floating $200$300 on a personal card while waiting for a reimbursement that may or may not arrive
Figure 5 8.5 Current strategies to enhance bioavailability While curcumin demonstrates immense therapeutic promise, its clinical application is significantly hampered by poor bioavailability due to limited absorption, rapid metabolism, and quick systemic elimination
