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3,4 Clinical interpretation of health versus disease depends severely on the availability of appropriate reference intervals

36 , 37 Although basket trials are recognized by the scientific community and regulatory agencies as robust and valid sources of evidence for the efficacy and safety of an investigational drug, building the overall program structure using both traditional and basket trials required careful clinical and statistical consideration to ensure a robust assessment of all endpoints with appropriate type I error control

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Or aware of the bacterium in the gut microbiota that induces natural production of GLP-1