retatrutide phase 2 trial type 2 diabetes weight loss 2024 VisualAbstract: reduces body by 17.5% in patients with obesity Retatrutide UK Guide: Key Facts

This is beyond what we see with any other medication on the market, and it is what we see with some bariatric surgeries, obesity medicine expert Jennah Siwak, MD, reported to her hundreds of thousands of followers on TikTok

Potential Impact: If 2.4mg/2.4mg achieves 20.4% weight loss, could 2.4mg/7.2mg achieve 25-27%

Contrary to most preceding obesity trials that predominantly enrolled women, this study included 51.8% men [3]

For perspective on where this lands against the field (placebo-adjusted weight loss): Type 2 diabetes TRANSCEND-T2D-1 (n = 537, 40 weeks) Published simultaneously in The Lancet

Average weight loss in studies is helpful for understanding trends, but individuals vary

The body conserves energy by reducing fidgeting, spontaneous movement, and activity intensity