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a greater proportion of people with MC4R deficiency had severe obesity and increased waist circumference ( P = 0.012)

[163] In March 2023, a Novo Nordisk official said, based on a randomized, double-blind study (NCT03548935 [164] ) funded by the company, that people using semaglutide to lose weight regained two-thirds of their original weight loss one year (52 weeks) after discontinuing use of the drug