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Comparing Western-type diet (WD) and fiber-enriched Mediterranean diet (FMD), the abundance of Firmicutes decreased, Bacteroidetes and Proteobacteria levels increased, and SCFA content increased, especially propionate and butyrate after FMD (Soldn et al., 2024)

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These findings suggest that Nrf2 exerts a pivotal function in counteracting inherent oxidative stress throughout the pathological process of PD, thereby further supporting its therapeutic potential

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It antagonizes haloperidol-induced behavioural supersensitivity to amphetamine which, results in dopaminergic neurotoxicity and nigrostriatum damage due to increased lipid peroxidation