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Clin J Am Soc Nephrol 2013;8:546553

This is mediated through the activation of the NF-B pathway (111)

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In -cells, GLP-1(936) activates GLP-1R, increasing cAMP and activating PKA and CREB to promote insulin secretion

The gap between the marketed mechanism (localized IGF-1 receptor activation driving hyperplasia) and lived experience (systemic effects including lethargy, joint pain, and unpredictable blood glucose swings) is what makes community discussion essential