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The drug is administered by injection once weekly under the skin of the thigh, upper arm, or abdomen, and can be taken with or without meals

Semaglutide works by slowing stomach emptying and reducing appetite signalseffects that alcohol can significantly interfere with

Some of the most common side effects (but not extremely frequent) are: fatigue or low energy difficulty sleeping nervousness and anxiety headache nausea or vomiting joint and muscle pain stomach cramps or pain Additional side effects include: loss of appetite diarrhea or constipation increased energy increased thirst dizziness skin rash sexual problems in males chills runny nose irritability or feeling down These symptoms may subside after the body adjusts to the medication

Stay hydrated to help flush out toxins and reduce treatment side effects

Methods Trial Designs The designs of the PIONEER 35, 7 and 8 trials have been reported previously and are summarised in Table 1 [7,8,9,10,11]

10.1016/j.molimm.2013.05.225 44 ZhangY.KamW