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This shift is a well-documented response to hypoxia, but in our model, it occurs as a direct consequence of SDH-b loss, independent of oxygen availability (Kluckova and Tennant 2018

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Loss of muscle mass, decreased bone growth, and the risks for cognitive deficiencies become higher

Jahangiry L, Farhangi MA (2021) Obesity paradigm and web-based weight loss programs: an updated systematic review and meta-analysis of randomized controlled trials