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While skeletal muscle detoxifies ammonia, hyperammonemia decreases serum BCAA and increases myostatin levels, both of which result in inhibition of mammalian target of rapamycin signaling and decreased protein synthesis [41, 42]

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Ptc, which is only expressed in a narrow stripe of cells just anterior to the AP compartment boundary by sensing the highest level of Hh, is a direct readout of Hh signalling