Finally, prospects for ferroptosis-based interventions and future directions point to several promising treatment avenues, including regulating iron homeostasis via chelators or TfR1/FPN modulation, using antioxidants and lipid peroxidation inhibitors to target GPX4 and ACSL4, or employing gene therapies and stem cell/exosome approaches to combat ferroptosis
The current study of ferroptosis in atherosclerosis has received considerable attention, but it is still at a very early stage, with current research focusing mainly on macrophages
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