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While small molecules like nicotine or oestrogen can be absorbed via a patch, GLP-1 molecules are roughly ten times larger than the limit for skin absorption

Plasma corticosterone levels of GLP-1R KD were also increased in response to acute stress, while baseline corticosterone levels were similar between GLP-1R KD and control, indicating that actions of GLP-1 may be partially by limiting acute stress-induced plasma corticosterone production

[DOI] [PubMed] 184.Oja S.S., Saransaari P

Inflammatory Pathways and Cellular Stress Research suggests that both peptides might influence inflammatory signaling cascades

PMC 4839509

Post metabolic bariatric surgery weight regain: the importance of GLP-1 levels