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In research models, it selectively binds to cardiolipin in the inner mitochondrial membrane

Compared with a high-risk-only policy, a universal policy provided additional indirect protection to older adults, preventing approximately 11,000 extra hospitalizations and approximately 1,000 extra deaths in those aged 65 years and older (representing a 3%-4% further reduction in burden for this group), reflecting community-level transmission benefits

Clinical trials have not identified hepatotoxicity as a characteristic adverse effect, and the medication is metabolised via pathways that place minimal burden on hepatic enzyme systems

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