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Peptides 150 , 170716 (2022)
After lipopolysaccharide/ Brucella abortus administration, the treatment of mice with olive extract (400 mg/kg p.o.) for 19 days significantly decreased immobility time and hyperalgesia along with an attenuation of oxidative stress (brain lipid peroxidation, reduced glutathione (GSH) levels, brain nitrite levels) and serum TNF- levels
Furthermore, the immunohistochemistry analysis evaluated the protective effects of the Au-PX-PLGA on dopaminergic neurons in the striatum and tyrosine hydroxylase, which is an essential enzyme in dopamine synthesis, served as the biomarker for dopaminergic neuron integrity
In a concentration-dependent manner, glutamate/malate-driven respiration is significantly uncoupled, increasing the state of respiration significantly vs
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