However, due to the unwanted side effects, such as glucose intolerance, insulin resistance, hypertension and edema, exerted by other functional domains of the intact hGH molecule limited its use as pharmacotherapy for obesity In other words, AOD9604 induces fat loss without the side effect of insulin resistance seen in many other peptides that stimulate growth hormone production/release
Bull Exp Biol Med 135(6):597599
The activation of CHAC1 leads to GSH depletion, thereby increasing oxidative stress and lipid peroxide accumulation, hallmarks of ferroptosis
Cellular senescence further contributes to lactate dysregulation in microglia (Gao et al., 2020
137 As a sulfur-containing amino acid, it possesses two potential binding sites for metals and is capable of binding and sequestering divalent copper (II), trivalent iron (III), lead, mercury, and cadmium ions
The peptide works through enzymatic suppression, not acute stimulation