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77,78,79 For example, Golodirsen, an ASO drug targeting the human Duchenne muscular dystrophy (DMD) gene, was introduced in the USA in 2019 by Sarepta Therapeutics to treat DMD patients with confirmed mutations amenable to exon 53 skipping
Published steady-state exposure puts 14 mg oral daily closer to a 0.5 mg weekly injection, and even 25 mg oral daily lands near a 0.9 mg weekly injection short of Wegovy 2.4 mg. Switching routes is an exposure change, not a brand swap
This is why combining cagrilintide with semaglutide produces synergistic effects