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This parameter was effectively higher in Fru (+ 110%), Fru + amlodipine (+ 26%), Fru + aminoguanidine (+ 20%), and Fru + NAC (+ 48%) than BSA (Fig

Adverse events leading to discontinuation including hypoglycaemia, vomiting, and diarrhoea were more common with combination regimens [6]

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2 Materials and methods 2.1 General computational methods Protein Data Bank (PDB) coordinates of the GLP-1GLP-1R (5VAI) (Zhang et al., 2017), Semaglutide (7KI0), Taspoglutide (7KI1) (Zhang et al., 2021), and liraglutide (4APD) were retrieved from the RCSB PDB server (www.rcsb.org)