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Additionally, it may help to reduce oxidative stress caused by environmental toxins

Human mast cell heterogeneity: Histamine release from mast cells dispersed from skin, lung, adenoids, tonsils, and colon in response to IgE-dependent and nonimmunoiogic stimuli

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Because it is applied directly to the skin, it completely bypasses your delayed digestive system , making it a much safer choice for fast relief than oral pain relievers that can upset a sensitive stomach

I also wouldnt prescribe them to people with untreated glucose control issues because of their effect on insulin resistance