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Proven treatments, including retinal photocoagulation (PRP), VEGF inhibitors, and corticosteroids, have demonstrated efficacy in both clinical trials and real-world applications [37]

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The Veteran Affairs-Diabetes in Nephropathy Study (VA-NEPHRON-D) and Aliskiren Trial in Type 2 Diabetes Using Cardiovascular and Renal Disease Endpoints (ALTITUDE) trials similarly assessed combination RAAS blockade but were discontinued early due to increased rates of hyperkalemia, AKI, and hypotension [88,89]

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Characterization of a Clostridium beijerinckii spo0A mutant and its application for butyl butyrate production