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Endocrinological Investigation 48 (12), 27612798

In one sentence, the mechanism is receptor-mediated: GHRP binding to GHS-R1a activates a Gq/11-coupled phospholipase C cascade that mobilises intracellular calcium and triggers exocytosis of stored GH from the anterior pituitary, independent of hypothalamic GHRH signalling

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This is particularly important in conditions like endometriosis

GLP-1 drugs, used to treat diabetes and obesity, seem to be a promising new treatment that helps target the root causes of migraine pain

Handbook of Cosmetic Science and Technology (2006)