"LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: from discovery to clinical proof of concept." Cell Metabolism
Additionally, some individuals may experience side effects, such as nausea or digestive issues, which often require adjusting the dosage under medical supervision
GLP-1 medications typically cause modest blood pressure reductions of 2-6 mmHg, which is generally beneficial
A variety of GLP-1RAs and analogs, such as Exendin-4 and Liraglutide, are currently being used to successfully treat T2D (7)
While not a direct side effect, you may pass out if the medication leads to severe dehydration or dangerously low blood sugar
The retatrutide vs tirzepatide comparison helps researchers evaluate whether the added complexity of retatrutide is worth it given their individual tolerance profile