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Orforglipron tucks into a compact pocket in the upper helical bundle, contacting transmembrane helices 1, 2, 3, and 7 plus a key extracellular residue, and not engaging helices 4, 5, and 6 the way the peptide does

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MTs in late-stage MASLD and hepatocellular carcinoma Furthermore, it has been shown that MASH can lead to a significant percentage of cirrhosis cases that cannot be attributed to a specific cause (idiopathic or cryptogenic)

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