While GLP-1RA has proven clinical efficacy, the need for more comprehensive studies, to ensure their long-term safety, is essential to optimize their therapeutic role and improve patient outcomes on a global scale
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While GLP-1 receptor agonists produce significant metabolic benefits independently, combining pharmacotherapy with comprehensive lifestyle modification enhances outcomes and promotes sustainable health improvements
For instance, berberine may have some blood-sugar-lowering effects, while green tea extract can have a mild impact on metabolism
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The CONFIDENCE is currently examining the effect of empagliflozin and finerenone combination therapy on kidney outcomes in CKD patients with diabetes [58]