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A synthetic derivative, bremelanotide (PT-141), was FDA-approved in 2019 for hypoactive sexual desire disorder in premenopausal women, validating the MC4R pathway even though MT2 itself is unapproved

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145,146 Inhibition of core pyroptotic mediators (NLRP3, caspase-1, GSDMD 147 ) improves hepatic histopathology in MASLD models, highlighting their therapeutic relevance