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This was based on extensive clinical trials focusing exclusively on weight loss outcomes

As an example, in the DURATION-8 study, while combination therapy produced greater HbA1c and body weight reductions, the effect was less than additive compared to the sum of individual drug effects, most likely because the efficacy of glucose-lowering therapies can depend on baseline glycaemic control [24]

"We know that when oxidation tips the balance toward too much GSSG, we get a redox potential shifted more to the positive than it should be," Reipa explains

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doi: 10.1111/apt.70007

in the pancreas, bone tissue, and vasculature