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In the brain, LC and ALC play important roles in cerebral bioenergetics and neuroprotection via a variety of mechanisms, including antioxidant properties, modulation and promotion of synaptic neurotransmission, particularly cholinergic neurotransmission, and their ability to enhance neuronal metabolism in mitochondria (Ahmed 2012)

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Indeed, when GSAAT is reduced with gradually increasing amounts of DTT prior to incubation with NEM, either one Cys (Band 1, with 0.1 mM DTT) or no Cys residue of GSAAT is accessible for mPEG binding (with DTT 1 mM) ( Figure 2C )

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Following the dose-escalation schedule in the product SmPC is important to minimise these effects, and several practical strategies can help manage digestive symptoms effectively