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Endocytosis appears somewhat slower than desensitization with time constants generally in the order of 5 minutes and reaching steady state in less than 30 minutes (Law et al., 2000

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Since the - arrestins 1 and 2 double knockouts are lethal mutations, the complete absence of arrestins on tolerance mechanisms cannot be assessed in vivo

While oral supplements are convenient, their effectiveness can vary due to absorption challenges

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