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Morphological abnormalities such as mitochondrial swelling, cristae disruptions, and structural irregularities, coupled with reduced ATP levels and heightened ROS production, are observed in ovarian aging across various oocyte species, indicating compromised clearance processes [153, 291]

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Mihajlovic M, Hariri S, Westphal KCG et al (2019) Safety evaluation of conditionally immortalized cells for renal replacement therapy