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In a meta-analysis of three trials, with a total of 1,119 participants, those with PAM variants were less responsive to the drugs and less successful in lowering their HbA1c, a measure of average blood sugar levels

doi: 10.1158/0008-5472.CAN-20-1488 18 DixonSJLembergKMLamprechtMRSkoutaRZaitsevEMGleasonCEet al

Each type of GLP-1 medication has a different dosing schedule and administration route

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The NYU Langone teams meta-analysis confirmed and broadened these findings

The mean reduction in body weight at 48 weeks was 24.2% in the 12-mg group the largest reduction observed to date in a Phase 2 trial of an anti-obesity medication. Jastreboff et al., New England Journal of Medicine, 2023 The Liver-Fat Result Beyond weight loss, retatrutide produced a result that surprised researchers: dramatic reductions in liver fat